Nightingale College of Nursing is fully owned and governed by the National Development Trust. The trust is registered under the Travancore-Cochin Literary Scientific and Charitable Societies Registration Act, 1953 Reg. No. 289/IV/2003, and was established in the year 2006. It is situated at Pachakkadu in Nedumangadu Municipality in Trivandrum.  Smt. Sreekumari Amma. C is the Managing Trustee of the Turst. Nightingale College of Nursing started its BSc Nursing Course in 2006 with an intake of 50 students. The course is approved by the Indian Nursing Council, Kerala Nurses and Midwives Council, affiliated to Kerala University and Kerala University of Health Sciences and is approved by the Govt. of Kerala (G.O. No GO (MS) NO 155/2005H&FWD).Lt. Col.(Retd) Isha Kunjappann is the Principal of Nightingale College of Nursing.

The Eight Batch of BSc. Nursing just graduated from the institution.